Species-Specific Structural Requirements of Alpha-Branched Trehalose Diester Mincle Agonists
نویسندگان
چکیده
منابع مشابه
Thermodynamic, hydration and structural characteristics of alpha,alpha-trehalose.
A nonreducing disaccharide, alpha,alpha-trehalose, accumulates endogenously in diverse anhydrobiotic organisms in their dehydrating process or prior to their desiccation, being thought to have a protective function either as a water replacement molecule or as a vitrification agent in the dry state. Trehalose acts also as a protectant against physiological stress, including freezing, ethanol and...
متن کاملTrehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo
The T-cell adjuvanticity of mycobacterial cord factor trehalose 6,6'-dimycolate (TDM) is well established. The identification of the C-type lectin Mincle on innate immune cells as the receptor for TDM and its synthetic analogue trehalose 6,6'-dibehenate (TDB) has raised interest in development of synthetic Mincle ligands as novel adjuvants. Trehalose mono- (TMXs) and diesters (TDXs) with symmet...
متن کاملStructural requirements of specific inhibitors for alpha-chymotrypsin. II. Effects of chain length and cyclic substituents.
It was shown in recent investigations that N-acylated amino acids and their derivatives can serve as inhibitors for cr-chymotrypsin. The available data indicated that a benzene ring in the acyl group was essential if the amino acid was devoid of an aromatic substituent, but that an aliphatic acyl group would do aswell if the amino acid was of the aromatic type (1, 2). Thus one, but not more tha...
متن کاملSensing Lipids with Mincle: Structure and Function
Mincle is a C-type lectin receptor that has emerged as an important player in innate immunity through its capacity to recognize a wide range of lipidic species derived from damaged/altered self and foreign microorganisms. Self-ligands include sterols (e.g., cholesterol), and β-glucosylceramides, and the protein SAP130, which is released upon cell death. Foreign lipids comprise those from both m...
متن کاملDefining the conformation of human mincle that interacts with mycobacterial trehalose dimycolate
Trehalose dimycolate, an unusual glycolipid in the outer membrane of Mycobacterium tuberculosis, stimulates macrophages by binding to the macrophage receptor mincle. This stimulation plays an important role both in infection by mycobacteria and in the use of derivatives of mycobacteria as adjuvants to enhance the immune response. The mechanism of trehalose dimycolate binding to the C-type carbo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2019
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.00338